S
- Samurai Pizza Cats (in progress)
- Second Reality Project 2, The
- Second Reality Project 2: Zycloboo's Challenge, The
- Secret Agent
- Secret of Evermore
- Secret of Mana
- Seiken Densetsu 3
- Shadowman
- Shaq Fu
- Shatterhand
- Shin Megami Tensei
- Shin Megami Tensei II
- Shinobi III: Return of the Dragon Master
- Shovel Knight
- Silver Surfer
- Simpsons: Bart and the Beanstalk, The
- Simpsons: Bart vs. the Space Mutants, The
- Simpsons: Bart vs. the World, The
- Simpsons, The (Arcade)
- Skyblazer
- Sly Cooper and the Thievius Raccoonus
- Smart Ball
- SMW 2012: Master Hand's Doomsday
- SMW: Grey Strikes Back
- SMW: Panic in the Mushroom Kingdom
- SMW: Panic in the Mushroom Kingdom 2
- SMW: The After Years
- SMW The Second Reality Project Reloaded
- SMW2+3: The Essence Star
- Sonic 3 & Knuckles
- Sonic 3D Blast
- Sonic CD
- Sonic Labyrinth
- Sonic the Hedgehog
- Sonic the Hedgehog (Master System)
- Soul Blazer
- Spanky's Quest
- Spelunky
- Spiderman & Venom: Maximum Carnage
- Splatterhouse
- Spyro 2: Ripto's Rage
- Spyro: Enter the Dragon (in progress)
- Spyro Orange: The Cortex Conspiracy
- Spyro the Dragon
- Star Fox
- Star Fox 64
- Startropics
- Stinger
- Street Fighter
- Street Fighter II
- Sunset Riders
- Super Adventure Island
- Super Adventure Island 2
- Super Bomberman
- Super Bomberman 2
- Super Bomberman 4
- Super Buster Bros.
- Super C
- Super Castlevania IV
- Super Ghouls 'n Ghosts
- Super Khold World
- Super Mario 2D Land
- Super Mario 63
- Super Mario 64
- Super Mario All-Stars
- Super Mario Bash
- Super Mario Bros. 3: A New Journey (in progress)
- Super Mario Bros. 3X
- Super Mario Bros. (Passive Run)
- Super Mario Bros. X - The Invasion 2
- Super Mario Cube Root of 3
- Super Mario Galaxy
- Super Mario Land
- Super Mario Land 2: Six Golden Coins
- Super Mario Land 3: Tatanga's Return
- Super Mario Omega
- Super Mario RPG: Legend of the Seven Stars
- Super Mario Sunshine
- Super Mario World
- Super Mario World Death Land
- Super Metroid
- Super Ninja Boy
- Super Paper Mario
- Super Princess Peach
- Super Smash Bros.
- Super Street Fighter II: The New Challengers
- Super Widget
- Superman 64
- Syobon Action
